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Multi-model UK score

UKB-MDRMF is a standardized framework that leverages UK Biobank's multimodal data to predict risks across 1,560 diseases. It integrates multimorbidity mechanisms, improving prediction performance and enabling comprehensive disease risk and interaction assessments. It separates generation from evaluation and utilizes a combination of models from Frontier labs including Anthropic and OpenAI. One model leads the generation phase, planning the task, iterating through. We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits that has been made available on the individuals in UKB, using a unified pipeline for PRS evaluation. We also release a benchmarking software tool to enable like-for-like. Design, Setting, and Participants: This prospective population-based UK Biobank cohort study assessed 4 dementia risk scores at baseline (2006-2010) and ascertained incident dementia during the following 10 years. Replication with a 20-year follow-up was based on the British Whitehall II study. 2% of 21 disease types showing improved.